BRD-K54256913_MK-1775_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K54256913_MK-1775_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ALOX5 arachidonate 5-lipoxygenase
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLK4 CDC-like kinase 4
COCH cochlin
CPA3 carboxypeptidase A3 (mast cell)
CSRP2 cysteine and glycine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DLX2 distal-less homeobox 2
DMXL2 Dmx-like 2
DSC3 desmocollin 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F13A1 coagulation factor XIII, A1 polypeptide
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GSTT1 glutathione S-transferase theta 1
H1F0 H1 histone family, member 0
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ICAM1 intercellular adhesion molecule 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL32 interleukin 32
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
KIAA0907 KIAA0907
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK3 kallikrein-related peptidase 3
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MAOB monoamine oxidase B
MICALL1 MICAL-like 1
MSMB microseminoprotein, beta-
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEU1 sialidase 1 (lysosomal sialidase)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKX3-1 NK3 homeobox 1
NOV nephroblastoma overexpressed
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
OPTN optineurin
PAIP1 poly(A) binding protein interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKP1 plakophilin 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRPF4 pre-mRNA processing factor 4
RAE1 ribonucleic acid export 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A2 S100 calcium binding protein A2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SRSF11 serine/arginine-rich splicing factor 11
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM9SF3 transmembrane 9 superfamily member 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
WBP5 WW domain binding protein 5
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ALDOA aldolase A, fructose-bisphosphate
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
C1QBP complement component 1, q subcomponent binding protein
CCDC85B coiled-coil domain containing 85B
CD200 CD200 molecule
CD34 CD34 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
COL15A1 collagen, type XV, alpha 1
COL5A1 collagen, type V, alpha 1
CTBP1 C-terminal binding protein 1
CTSZ cathepsin Z
DACT1 dishevelled-binding antagonist of beta-catenin 1
DERA deoxyribose-phosphate aldolase (putative)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFHD1 EF-hand domain family, member D1
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHOD3 formin homology 2 domain containing 3
FSTL1 follistatin-like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM1 interferon induced transmembrane protein 1
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6E lymphocyte antigen 6 complex, locus E
MDFIC MyoD family inhibitor domain containing
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MMP11 matrix metallopeptidase 11
MOCOS molybdenum cofactor sulfurase
MTA1 metastasis associated 1
NUP210 nucleoporin 210kDa
PDE10A phosphodiesterase 10A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGAM1 phosphoglycerate mutase 1 (brain)
PLA2G16 phospholipase A2, group XVI
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCH1 phospholipase C, eta 1
PSAT1 phosphoserine aminotransferase 1
RAB15 RAB15, member RAS oncogene family
REEP5 receptor accessory protein 5
RGS16 regulator of G-protein signaling 16
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SRPX sushi-repeat containing protein, X-linked
SYNJ2 synaptojanin 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
VCAN versican
ZNF423 zinc finger protein 423