BRD-K54256913_MK-1775_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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82 genes differentially expressed following the BRD-K54256913_MK-1775_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
ANXA1 annexin A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
CA9 carbonic anhydrase IX
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES2 carboxylesterase 2
CHIC2 cysteine-rich hydrophobic domain 2
CYB5A cytochrome b5 type A (microsomal)
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXT1 exostosin glycosyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM63A family with sequence similarity 63, member A
FGL2 fibrinogen-like 2
FN1 fibronectin 1
GATA6 GATA binding protein 6
GLS glutaminase
GPX3 glutathione peroxidase 3
HOPX HOP homeobox
HYOU1 hypoxia up-regulated 1
IGHA1 immunoglobulin heavy constant alpha 1
IGLV2-23 immunoglobulin lambda variable 2-23
ISOC1 isochorismatase domain containing 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEST mesoderm specific transcript
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PGC progastricsin (pepsinogen C)
PLK2 polo-like kinase 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TBC1D31 TBC1 domain family, member 31
TGM2 transglutaminase 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRBC1 T cell receptor beta constant 1
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
BACE2 beta-site APP-cleaving enzyme 2
CA12 carbonic anhydrase XII
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
DCLK1 doublecortin-like kinase 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
FGFR2 fibroblast growth factor receptor 2
GPM6B glycoprotein M6B
HLTF helicase-like transcription factor
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO6 myosin VI
NEFL neurofilament, light polypeptide
NID1 nidogen 1
NKTR natural killer cell triggering receptor
NOV nephroblastoma overexpressed
NPEPL1 aminopeptidase-like 1
PDZRN3 PDZ domain containing ring finger 3
PON2 paraoxonase 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SRRM2 serine/arginine repetitive matrix 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC1 transforming, acidic coiled-coil containing protein 1
TCTN1 tectonic family member 1
YME1L1 YME1-like 1 ATPase
ZMYM2 zinc finger, MYM-type 2