BRD-K54256913_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K54256913_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN4 actinin, alpha 4
AGRN agrin
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAPN2 calpain 2, (m/II) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL18A1 collagen, type XVIII, alpha 1
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
EXT1 exostosin glycosyltransferase 1
FDXR ferredoxin reductase
FGFR2 fibroblast growth factor receptor 2
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GPC4 glypican 4
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST2H2BE histone cluster 2, H2be
HMG20B high mobility group 20B
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB5 integrin, beta 5
KRT81 keratin 81, type II
LMNA lamin A/C
MVP major vault protein
NT5E 5'-nucleotidase, ecto (CD73)
P4HB prolyl 4-hydroxylase, beta polypeptide
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLXNB2 plexin B2
PYGB phosphorylase, glycogen; brain
RAI14 retinoic acid induced 14
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RPS27L ribosomal protein S27-like
SDC1 syndecan 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
TGFA transforming growth factor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPM1 tropomyosin 1 (alpha)
TRIM2 tripartite motif containing 2
TUBA4A tubulin, alpha 4a
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
ATP9A ATPase, class II, type 9A
BLM Bloom syndrome, RecQ helicase-like
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNE2 cyclin E2
CD34 CD34 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CGRRF1 cell growth regulator with ring finger domain 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
COL6A3 collagen, type VI, alpha 3
CPNE3 copine III
DCK deoxycytidine kinase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
FAR2 fatty acyl CoA reductase 2
FEN1 flap structure-specific endonuclease 1
GDI2 GDP dissociation inhibitor 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
KIF11 kinesin family member 11
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MSH2 mutS homolog 2
MSH6 mutS homolog 6
NET1 neuroepithelial cell transforming 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RBBP4 retinoblastoma binding protein 4
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TOPBP1 topoisomerase (DNA) II binding protein 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WEE1 WEE1 G2 checkpoint kinase