BRD-K54233340_Dorsomorphin dihydrochloride_HCT116_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K54233340_Dorsomorphin dihydrochloride_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM17 ADAM metallopeptidase domain 17
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANPEP alanyl (membrane) aminopeptidase
ANXA10 annexin A10
APOA1 apolipoprotein A-I
AREG amphiregulin
ATF3 activating transcription factor 3
ATRN attractin
BHLHE40 basic helix-loop-helix family, member e40
C6ORF48 chromosome 6 open reading frame 48
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CST3 cystatin C
CSTA cystatin A (stefin A)
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
ELOVL5 ELOVL fatty acid elongase 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXG1 forkhead box G1
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GRB10 growth factor receptor-bound protein 10
GREB1 growth regulation by estrogen in breast cancer 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BH histone cluster 1, H2bh
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAMP1 lysosomal-associated membrane protein 1
LRRC17 leucine rich repeat containing 17
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MATN2 matrilin 2
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
NCK2 NCK adaptor protein 2
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFML3 olfactomedin-like 3
PCDH7 protocadherin 7
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PDZK1 PDZ domain containing 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER2 period circadian clock 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA1 paraneoplastic Ma antigen 1
PPARG peroxisome proliferator-activated receptor gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RASA4 RAS p21 protein activator 4
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL38 ribosomal protein L38
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SESN1 sestrin 1
SFN stratifin
SH3BGR SH3 domain binding glutamate-rich protein
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC44A4 solute carrier family 44, member 4
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TACSTD2 tumor-associated calcium signal transducer 2
TCTA T-cell leukemia translocation altered
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TUBB2A tubulin, beta 2A class IIa
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
WT1 Wilms tumor 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADM adrenomedullin
ARMCX1 armadillo repeat containing, X-linked 1
ATMIN ATM interactor
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BMP4 bone morphogenetic protein 4
C10ORF10 chromosome 10 open reading frame 10
CANT1 calcium activated nucleotidase 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNB2 cyclin B2
CCNF cyclin F
CDC25B cell division cycle 25B
CEMIP cell migration inducing protein, hyaluronan binding
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL12 chemokine (C-X-C motif) ligand 12
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM69A family with sequence similarity 69, member A
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
GNLY granulysin
GPNMB glycoprotein (transmembrane) nmb
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
LRRN3 leucine rich repeat neuronal 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MRPS12 mitochondrial ribosomal protein S12
MRPS2 mitochondrial ribosomal protein S2
MZB1 marginal zone B and B1 cell-specific protein
NAV2 neuron navigator 2
NKG7 natural killer cell granule protein 7
NOV nephroblastoma overexpressed
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
OXA1L oxidase (cytochrome c) assembly 1-like
PCP4 Purkinje cell protein 4
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRF1 perforin 1 (pore forming protein)
RAD51AP1 RAD51 associated protein 1
RRM2 ribonucleotide reductase M2
SDC1 syndecan 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM2 tripartite motif containing 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
VSNL1 visinin-like 1
ZIC1 Zic family member 1