BRD-K54233340_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K54233340_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADCK3 aarF domain containing kinase 3
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANO10 anoctamin 10
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOD apolipoprotein D
AQP9 aquaporin 9
AREG amphiregulin
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASGR2 asialoglycoprotein receptor 2
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BTG3 BTG family, member 3
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CD163 CD163 molecule
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CFH complement factor H
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CPQ carboxypeptidase Q
CPVL carboxypeptidase, vitellogenic-like
CRIP2 cysteine-rich protein 2
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DLK1 delta-like 1 homolog (Drosophila)
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM171A1 family with sequence similarity 171, member A1
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GUK1 guanylate kinase 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
KIAA0907 KIAA0907
KLHL2 kelch-like family member 2
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPIN1 lipin 1
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALL mal, T-cell differentiation protein-like
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAUR plasminogen activator, urokinase receptor
PON3 paraoxonase 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAD Ras-related associated with diabetes
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCG5 secretogranin V
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SFN stratifin
SH3BGR SH3 domain binding glutamate-rich protein
SNX3 sorting nexin 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STK17B serine/threonine kinase 17b
STS steroid sulfatase (microsomal), isozyme S
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TTR transthyretin
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
VAMP3 vesicle-associated membrane protein 3
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASXL2 additional sex combs like transcriptional regulator 2
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
AXIN1 axin 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL2 B-cell CLL/lymphoma 2
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHL1 cell adhesion molecule L1-like
COL3A1 collagen, type III, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM57A family with sequence similarity 57, member A
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HOXC10 homeobox C10
IGF1R insulin-like growth factor 1 receptor
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KIAA0485 uncharacterized LOC57235
KIF2C kinesin family member 2C
KLHL9 kelch-like family member 9
LAT2 linker for activation of T cells family, member 2
LPAR2 lysophosphatidic acid receptor 2
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MEGF9 multiple EGF-like-domains 9
MID1IP1 MID1 interacting protein 1
MMP12 matrix metallopeptidase 12
MRPL57 mitochondrial ribosomal protein L57
MRPS31 mitochondrial ribosomal protein S31
MYB v-myb avian myeloblastosis viral oncogene homolog
NAV2 neuron navigator 2
NEBL nebulette
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOTCH1 notch 1
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
OLIG2 oligodendrocyte lineage transcription factor 2
OPN3 opsin 3
OXTR oxytocin receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDZRN3 PDZ domain containing ring finger 3
PFKP phosphofructokinase, platelet
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCD protein kinase C, delta
PSRC1 proline/serine-rich coiled-coil 1
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC38A1 solute carrier family 38, member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SPDEF SAM pointed domain containing ETS transcription factor
SULF1 sulfatase 1
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TACC2 transforming, acidic coiled-coil containing protein 2
TBC1D31 TBC1 domain family, member 31
TBX2 T-box 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM33 tripartite motif containing 33
TRIP6 thyroid hormone receptor interactor 6
TRPS1 trichorhinophalangeal syndrome I
TSEN2 TSEN2 tRNA splicing endonuclease subunit
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZNF146 zinc finger protein 146
ZNF652 zinc finger protein 652