BRD-K54233340_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K54233340_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AREG amphiregulin
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BEX4 brain expressed, X-linked 4
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CD163 CD163 molecule
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CPQ carboxypeptidase Q
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FASTKD5 FAST kinase domains 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS7 growth arrest-specific 7
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GMFG glia maturation factor, gamma
GPM6B glycoprotein M6B
GTF2B general transcription factor IIB
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LAGE3 L antigen family, member 3
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
METTL7A methyltransferase like 7A
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
PDLIM5 PDZ and LIM domain 5
PER2 period circadian clock 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PRNP prion protein
PRR7 proline rich 7 (synaptic)
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SST somatostatin
STC2 stanniocalcin 2
TBPL1 TBP-like 1
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN7 tetraspanin 7
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AK1 adenylate kinase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BRCA1 breast cancer 1, early onset
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP55 centrosomal protein 55kDa
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIXDC1 DIX domain containing 1
DPP4 dipeptidyl-peptidase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM57A family with sequence similarity 57, member A
FNBP1 formin binding protein 1
GOLGA8B golgin A8 family, member B
GSTA4 glutathione S-transferase alpha 4
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITGB1BP1 integrin beta 1 binding protein 1
KRT18 keratin 18, type I
MCM5 minichromosome maintenance complex component 5
MSH6 mutS homolog 6
MTCL1 microtubule crosslinking factor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRPF4 pre-mRNA processing factor 4
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RBPMS RNA binding protein with multiple splicing
REEP1 receptor accessory protein 1
SOX11 SRY (sex determining region Y)-box 11
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TRAPPC3 trafficking protein particle complex 3
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF451 zinc finger protein 451