BRD-K54018158_MLS-0216981_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K54018158_MLS-0216981_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
C3ORF14 chromosome 3 open reading frame 14
CD1E CD1e molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKAP4 cytoskeleton-associated protein 4
CLGN calmegin
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
FAR2 fatty acyl CoA reductase 2
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPX2 glutathione peroxidase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LYRM1 LYR motif containing 1
NAMPT nicotinamide phosphoribosyltransferase
NAV3 neuron navigator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYCR1 pyrroline-5-carboxylate reductase 1
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TRIB3 tribbles pseudokinase 3
TST thiosulfate sulfurtransferase (rhodanese)
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
CCNB1 cyclin B1
CD24 CD24 molecule
CPA3 carboxypeptidase A3 (mast cell)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCR4 chemokine (C-X-C motif) receptor 4
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP7 fatty acid binding protein 7, brain
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GNAS GNAS complex locus
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
KRT17 keratin 17, type I
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
MOK MOK protein kinase
OLFM4 olfactomedin 4
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF167 ring finger protein 167
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNS3 tensin 3
VCAN versican