BRD-K53987533_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K53987533_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CST3 cystatin C
CTH cystathionine gamma-lyase
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FHL2 four and a half LIM domains 2
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
LY96 lymphocyte antigen 96
MANF mesencephalic astrocyte-derived neurotrophic factor
MAOA monoamine oxidase A
MICB MHC class I polypeptide-related sequence B
MLPH melanophilin
MT1F metallothionein 1F
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOTCH2NL notch 2 N-terminal like
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRL platelet-derived growth factor receptor-like
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PLAC8 placenta-specific 8
PSAP prosaposin
PYCR1 pyrroline-5-carboxylate reductase 1
RAD9A RAD9 homolog A (S. pombe)
RBM47 RNA binding motif protein 47
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A6 solute carrier family 16, member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35B1 solute carrier family 35, member B1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SORD sorbitol dehydrogenase
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STC2 stanniocalcin 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
XBP1 X-box binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AMIGO2 adhesion molecule with Ig-like domain 2
AOC3 amine oxidase, copper containing 3
AREG amphiregulin
BEX1 brain expressed, X-linked 1
CA9 carbonic anhydrase IX
CARD10 caspase recruitment domain family, member 10
CAV2 caveolin 2
CCND2 cyclin D2
CCNF cyclin F
CD69 CD69 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPE centromere protein E, 312kDa
CNN3 calponin 3, acidic
CSRP2 cysteine and glycine-rich protein 2
DDHD2 DDHD domain containing 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MECOM MDS1 and EVI1 complex locus
MN1 meningioma (disrupted in balanced translocation) 1
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIK1 salt-inducible kinase 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNX7 sorting nexin 7
SRSF2 serine/arginine-rich splicing factor 2
STK39 serine threonine kinase 39
SULF1 sulfatase 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TRIM24 tripartite motif containing 24
TSPAN8 tetraspanin 8
XIST X inactive specific transcript (non-protein coding)