BRD-K53972329_ruxolitinib_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K53972329_ruxolitinib_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CLIC5 chloride intracellular channel 5
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
FAM171A1 family with sequence similarity 171, member A1
GLRX glutaredoxin (thioltransferase)
HIST1H2AC histone cluster 1, H2ac
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IL13RA1 interleukin 13 receptor, alpha 1
KRT81 keratin 81, type II
LAMP3 lysosomal-associated membrane protein 3
MTUS1 microtubule associated tumor suppressor 1
NARFL nuclear prelamin A recognition factor-like
PRAME preferentially expressed antigen in melanoma
RIN2 Ras and Rab interactor 2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCARB2 scavenger receptor class B, member 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TOX3 TOX high mobility group box family member 3
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
CIRBP cold inducible RNA binding protein
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
GSTM3 glutathione S-transferase mu 3 (brain)
HEBP1 heme binding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IGFBP7 insulin-like growth factor binding protein 7
KIAA0101 KIAA0101
MET MET proto-oncogene, receptor tyrosine kinase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PRDX2 peroxiredoxin 2
PTTG1 pituitary tumor-transforming 1
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX3 runt-related transcription factor 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLE2 transducin-like enhancer of split 2
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13