BRD-K53972329_ruxolitinib_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K53972329_ruxolitinib_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD93 CD93 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DLK1 delta-like 1 homolog (Drosophila)
EMP1 epithelial membrane protein 1
ETV5 ets variant 5
EZR ezrin
FOCAD focadhesin
IER5 immediate early response 5
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
TGFA transforming growth factor, alpha
TRIB2 tribbles pseudokinase 2
TYRP1 tyrosinase-related protein 1
VWF von Willebrand factor

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
CDKN2A cyclin-dependent kinase inhibitor 2A
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EPHA3 EPH receptor A3
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GSTM3 glutathione S-transferase mu 3 (brain)
H3F3B H3 histone, family 3B (H3.3B)
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0195 KIAA0195
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPO myeloperoxidase
MRPS7 mitochondrial ribosomal protein S7
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SAP30BP SAP30 binding protein
SPON1 spondin 1, extracellular matrix protein
SUMO2 small ubiquitin-like modifier 2
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
VAV3 vav 3 guanine nucleotide exchange factor