BRD-K53972329_ruxolitinib_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K53972329_ruxolitinib_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX15B arachidonate 15-lipoxygenase, type B
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
APOC1 apolipoprotein C-I
AUTS2 autism susceptibility candidate 2
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHMT betaine--homocysteine S-methyltransferase
BLVRB biliverdin reductase B
CAT catalase
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIC5 chloride intracellular channel 5
DAPK1 death-associated protein kinase 1
DCT dopachrome tautomerase
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFB1 defensin, beta 1
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FAR2 fatty acyl CoA reductase 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
GSTA4 glutathione S-transferase alpha 4
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSDL2 hydroxysteroid dehydrogenase like 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LIMCH1 LIM and calponin homology domains 1
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MLANA melan-A
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOV nephroblastoma overexpressed
P3H2 prolyl 3-hydroxylase 2
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PHYH phytanoyl-CoA 2-hydroxylase
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SESN1 sestrin 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TSKU tsukushi, small leucine rich proteoglycan
TYR tyrosinase
TYRP1 tyrosinase-related protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANXA3 annexin A3
APOD apolipoprotein D
CALD1 caldesmon 1
CCNE2 cyclin E2
CHD1 chromodomain helicase DNA binding protein 1
CLDND1 claudin domain containing 1
COL11A1 collagen, type XI, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTPS1 CTP synthase 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFL6 EGF-like-domain, multiple 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FGFR1 fibroblast growth factor receptor 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
GYG1 glycogenin 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
INPP1 inositol polyphosphate-1-phosphatase
IPO13 importin 13
ITGB5 integrin, beta 5
KCTD12 potassium channel tetramerization domain containing 12
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCAM melanoma cell adhesion molecule
MMP9 matrix metallopeptidase 9
MSLN mesothelin
ODC1 ornithine decarboxylase 1
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PFKP phosphofructokinase, platelet
PRNP prion protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMTN smoothelin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQRDL sulfide quinone reductase-like (yeast)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
SVIL supervillin
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMPRSS3 transmembrane protease, serine 3
VIM vimentin
WT1 Wilms tumor 1
ZBTB18 zinc finger and BTB domain containing 18