BRD-K53959060_Indirubin-3-oxime_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K53959060_Indirubin-3-oxime_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ASS1 argininosuccinate synthase 1
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
C1ORF54 chromosome 1 open reading frame 54
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
E2F2 E2F transcription factor 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EPN2 epsin 2
ESR1 estrogen receptor 1
FBP1 fructose-1,6-bisphosphatase 1
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
GAA glucosidase, alpha; acid
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HNMT histamine N-methyltransferase
HSPA13 heat shock protein 70kDa family, member 13
IFITM3 interferon induced transmembrane protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP1 inositol polyphosphate-1-phosphatase
KRT13 keratin 13, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP1B microtubule-associated protein 1B
MMP12 matrix metallopeptidase 12
MTDH metadherin
NCAM1 neural cell adhesion molecule 1
NUCB2 nucleobindin 2
OLFM1 olfactomedin 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA5 protein disulfide isomerase family A, member 5
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A2 S100 calcium binding protein A2
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC35G2 solute carrier family 35, member G2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
SSR4 signal sequence receptor, delta
TDO2 tryptophan 2,3-dioxygenase
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AEBP1 AE binding protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANGPT1 angiopoietin 1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CCND3 cyclin D3
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CKS1B CDC28 protein kinase regulatory subunit 1B
CSTA cystatin A (stefin A)
CTSV cathepsin V
DEFA4 defensin, alpha 4, corticostatin
DNM1L dynamin 1-like
DYNLRB1 dynein, light chain, roadblock-type 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR3 fibroblast growth factor receptor 3
GADD45B growth arrest and DNA-damage-inducible, beta
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT14 keratin 14, type I
LXN latexin
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PLBD1 phospholipase B domain containing 1
RABGAP1L RAB GTPase activating protein 1-like
SCD5 stearoyl-CoA desaturase 5
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
STX7 syntaxin 7
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
WDTC1 WD and tetratricopeptide repeats 1
ZMYND8 zinc finger, MYND-type containing 8