BRD-K53501402_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K53501402_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAX BCL2-associated X protein
CD163 CD163 molecule
DDIT4 DNA-damage-inducible transcript 4
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
GADD45A growth arrest and DNA-damage-inducible, alpha
HIST2H2BE histone cluster 2, H2be
MAOA monoamine oxidase A
MVP major vault protein
PDLIM4 PDZ and LIM domain 4
PLAU plasminogen activator, urokinase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAT1 spermidine/spermine N1-acetyltransferase 1
SESN1 sestrin 1
SLC22A18 solute carrier family 22, member 18
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CCNB2 cyclin B2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
GTSE1 G-2 and S-phase expressed 1
HSPB8 heat shock 22kDa protein 8
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MSMB microseminoprotein, beta-
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY neuropeptide Y
NUP98 nucleoporin 98kDa
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RHOBTB3 Rho-related BTB domain containing 3
RRP1B ribosomal RNA processing 1B
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMS spermine synthase
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
TOP2A topoisomerase (DNA) II alpha 170kDa
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1