BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGA aspartylglucosaminidase
ALDOB aldolase B, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARG1 arginase 1
BAMBI BMP and activin membrane-bound inhibitor
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD24 CD24 molecule
CD48 CD48 molecule
CD59 CD59 molecule, complement regulatory protein
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DSTN destrin (actin depolymerizing factor)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBXO11 F-box protein 11
FGFR3 fibroblast growth factor receptor 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GMFG glia maturation factor, gamma
GSTA1 glutathione S-transferase alpha 1
HIST1H2BG histone cluster 1, H2bg
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
KIAA0226L KIAA0226-like
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LMO4 LIM domain only 4
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A10 S100 calcium binding protein A10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAGLN transgelin
TAGLN2 transgelin 2
TDO2 tryptophan 2,3-dioxygenase
THY1 Thy-1 cell surface antigen
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VNN1 vanin 1

decreased expression

Symbol Name
AFF1 AF4/FMR2 family, member 1
AGO2 argonaute RISC catalytic component 2
AKAP10 A kinase (PRKA) anchor protein 10
ANKRD17 ankyrin repeat domain 17
ANKRD36B ankyrin repeat domain 36B
AURKB aurora kinase B
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNF cyclin F
CDC25B cell division cycle 25B
CDCP1 CUB domain containing protein 1
CEP55 centrosomal protein 55kDa
CHD7 chromodomain helicase DNA binding protein 7
CHD9 chromodomain helicase DNA binding protein 9
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
DUSP4 dual specificity phosphatase 4
EDRF1 erythroid differentiation regulatory factor 1
ETV5 ets variant 5
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FNBP4 formin binding protein 4
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FSTL1 follistatin-like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GOSR1 golgi SNAP receptor complex member 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
LARP4 La ribonucleoprotein domain family, member 4
LOC100272216 uncharacterized LOC100272216
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED13 mediator complex subunit 13
MGLL monoglyceride lipase
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MYO10 myosin X
N4BP2L2 NEDD4 binding protein 2-like 2
NPAS2 neuronal PAS domain protein 2
NPAT nuclear protein, ataxia-telangiectasia locus
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PFKP phosphofructokinase, platelet
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMM2 phosphomannomutase 2
PPARG peroxisome proliferator-activated receptor gamma
PRRC2C proline-rich coiled-coil 2C
PTK2 protein tyrosine kinase 2
PXDN peroxidasin
REV1 REV1, polymerase (DNA directed)
RNMT RNA (guanine-7-) methyltransferase
RRP1B ribosomal RNA processing 1B
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SETD5 SET domain containing 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SON SON DNA binding protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TBC1D31 TBC1 domain family, member 31
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TMEM63A transmembrane protein 63A
TNS3 tensin 3
UBR5 ubiquitin protein ligase E3 component n-recognin 5
WDR37 WD repeat domain 37
WSB1 WD repeat and SOCS box containing 1
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF131 zinc finger protein 131