BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AGR2 anterior gradient 2
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
CCND2 cyclin D2
CD52 CD52 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CXADR coxsackie virus and adenovirus receptor
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPHA4 EPH receptor A4
FN1 fibronectin 1
FZD5 frizzled class receptor 5
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
HEBP2 heme binding protein 2
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HPSE heparanase
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL7R interleukin 7 receptor
ITM2C integral membrane protein 2C
KLF10 Kruppel-like factor 10
LBH limb bud and heart development
LCN2 lipocalin 2
LGALS2 lectin, galactoside-binding, soluble, 2
MMP9 matrix metallopeptidase 9
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHACTR2 phosphatase and actin regulator 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SCG5 secretogranin V
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOCS2 suppressor of cytokine signaling 2
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
TSPAN6 tetraspanin 6
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AKAP11 A kinase (PRKA) anchor protein 11
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CD58 CD58 molecule
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5 eukaryotic translation initiation factor 5
FAM3C family with sequence similarity 3, member C
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIF14 kinesin family member 14
KRT7 keratin 7, type II
KYNU kynureninase
L1CAM L1 cell adhesion molecule
LYPLA1 lysophospholipase I
MTA1 metastasis associated 1
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
PLAC8 placenta-specific 8
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PRRC2C proline-rich coiled-coil 2C
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPATA20 spermatogenesis associated 20
SRP72 signal recognition particle 72kDa
STK26 serine/threonine protein kinase 26
TCERG1 transcription elongation regulator 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
UBE3C ubiquitin protein ligase E3C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
YME1L1 YME1-like 1 ATPase
ZDHHC6 zinc finger, DHHC-type containing 6