BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
AKAP12 A kinase (PRKA) anchor protein 12
ARG2 arginase 2
ASMTL acetylserotonin O-methyltransferase-like
BASP1 brain abundant, membrane attached signal protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FAM49A family with sequence similarity 49, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GPX2 glutathione peroxidase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HBD hemoglobin, delta
HSPA1A heat shock 70kDa protein 1A
IFI6 interferon, alpha-inducible protein 6
MSX1 msh homeobox 1
NEFH neurofilament, heavy polypeptide
NLGN4X neuroligin 4, X-linked
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
RAP1GAP RAP1 GTPase activating protein
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
SFN stratifin
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TCEA2 transcription elongation factor A (SII), 2
TCEAL2 transcription elongation factor A (SII)-like 2
TSC22D3 TSC22 domain family, member 3
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ASS1 argininosuccinate synthase 1
CCDC85B coiled-coil domain containing 85B
CCNE2 cyclin E2
FAP fibroblast activation protein, alpha
GPRC5A G protein-coupled receptor, class C, group 5, member A
IGFBP4 insulin-like growth factor binding protein 4
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PRDX2 peroxiredoxin 2
PRSS2 protease, serine, 2 (trypsin 2)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
UBE2A ubiquitin-conjugating enzyme E2A
VEGFA vascular endothelial growth factor A