BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AKR1C1 aldo-keto reductase family 1, member C1
ANKHD1 ankyrin repeat and KH domain containing 1
APOD apolipoprotein D
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BCL2A1 BCL2-related protein A1
BTG3 BTG family, member 3
C1ORF54 chromosome 1 open reading frame 54
C6ORF62 chromosome 6 open reading frame 62
CD24 CD24 molecule
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
CPB1 carboxypeptidase B1 (tissue)
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM49A family with sequence similarity 49, member A
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FEM1B fem-1 homolog b (C. elegans)
FN1 fibronectin 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLS glutaminase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GTPBP8 GTP-binding protein 8 (putative)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA5 homeobox A5
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL1RAP interleukin 1 receptor accessory protein
JAG1 jagged 1
KIF5B kinesin family member 5B
KLF10 Kruppel-like factor 10
KLHL7 kelch-like family member 7
KRT14 keratin 14, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSP1 lymphocyte-specific protein 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
NANS N-acetylneuraminic acid synthase
NDRG2 NDRG family member 2
NEFH neurofilament, heavy polypeptide
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PAPOLA poly(A) polymerase alpha
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGCC regulator of cell cycle
RNF11 ring finger protein 11
S100A1 S100 calcium binding protein A1
S100A10 S100 calcium binding protein A10
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SKP1 S-phase kinase-associated protein 1
SLIT2 slit homolog 2 (Drosophila)
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STK17B serine/threonine kinase 17b
TEK TEK tyrosine kinase, endothelial
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNNI2 troponin I type 2 (skeletal, fast)
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
USP1 ubiquitin specific peptidase 1
USP33 ubiquitin specific peptidase 33
VGLL4 vestigial-like family member 4
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALOX5 arachidonate 5-lipoxygenase
ANKRD36B ankyrin repeat domain 36B
ATXN1 ataxin 1
AVL9 AVL9 homolog (S. cerevisiase)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE41 basic helix-loop-helix family, member e41
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C2CD5 C2 calcium-dependent domain containing 5
CCNF cyclin F
CD58 CD58 molecule
CDC25B cell division cycle 25B
CDCP1 CUB domain containing protein 1
CDK12 cyclin-dependent kinase 12
CEP192 centrosomal protein 192kDa
CHD9 chromodomain helicase DNA binding protein 9
CNOT4 CCR4-NOT transcription complex, subunit 4
CPD carboxypeptidase D
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST1 cystatin SN
DENND2D DENN/MADD domain containing 2D
DHRS2 dehydrogenase/reductase (SDR family) member 2
DST dystonin
EDRF1 erythroid differentiation regulatory factor 1
ELANE elastase, neutrophil expressed
ENOSF1 enolase superfamily member 1
ETV5 ets variant 5
FAM208A family with sequence similarity 208, member A
FBXO28 F-box protein 28
FHL2 four and a half LIM domains 2
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOXD1 forkhead box D1
FRY furry homolog (Drosophila)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8A golgin A8 family, member A
GSAP gamma-secretase activating protein
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
H1F0 H1 histone family, member 0
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KRT7 keratin 7, type II
LAMA4 laminin, alpha 4
LOC100272216 uncharacterized LOC100272216
LYST lysosomal trafficking regulator
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MPHOSPH8 M-phase phosphoprotein 8
MTCL1 microtubule crosslinking factor 1
N4BP2L2 NEDD4 binding protein 2-like 2
NF1 neurofibromin 1
NFX1 nuclear transcription factor, X-box binding 1
NMT1 N-myristoyltransferase 1
NT5E 5'-nucleotidase, ecto (CD73)
PHIP pleckstrin homology domain interacting protein
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PSPC1 paraspeckle component 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PXDN peroxidasin
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RBM26 RNA binding motif protein 26
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
SETDB1 SET domain, bifurcated 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPG11 spastic paraplegia 11 (autosomal recessive)
TCERG1 transcription elongation regulator 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TPP2 tripeptidyl peptidase II
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRRAP transformation/transcription domain-associated protein
TSPAN8 tetraspanin 8
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZCCHC6 zinc finger, CCHC domain containing 6
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMYM2 zinc finger, MYM-type 2
ZNF451 zinc finger protein 451