BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AKAP8L A kinase (PRKA) anchor protein 8-like
ALB albumin
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AREG amphiregulin
ARG1 arginase 1
ARG2 arginase 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BCL2A1 BCL2-related protein A1
C1ORF54 chromosome 1 open reading frame 54
CALD1 caldesmon 1
CD14 CD14 molecule
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDO1 cysteine dioxygenase type 1
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSK cathepsin K
CTSV cathepsin V
CTTN cortactin
CUX2 cut-like homeobox 2
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DHCR7 7-dehydrocholesterol reductase
DLX2 distal-less homeobox 2
DPT dermatopontin
DSP desmoplakin
EGR2 early growth response 2
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
F11R F11 receptor
FBXO11 F-box protein 11
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FST follistatin
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
HAMP hepcidin antimicrobial peptide
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HOXA10 homeobox A10
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGLL1 immunoglobulin lambda-like polypeptide 1
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LEPROT leptin receptor overlapping transcript
LUM lumican
MCOLN1 mucolipin 1
MIR22HG MIR22 host gene
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NMT2 N-myristoyltransferase 2
NMU neuromedin U
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
OSBPL8 oxysterol binding protein-like 8
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAK1IP1 PAK1 interacting protein 1
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFC platelet derived growth factor C
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PFN2 profilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLTP phospholipid transfer protein
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTTG1IP pituitary tumor-transforming 1 interacting protein
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SDS serine dehydratase
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SORT1 sortilin 1
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TFR2 transferrin receptor 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TSPAN13 tetraspanin 13
TTC3 tetratricopeptide repeat domain 3
TUBB2A tubulin, beta 2A class IIa
TUSC3 tumor suppressor candidate 3
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
USP1 ubiquitin specific peptidase 1
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABR active BCR-related
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL2 additional sex combs like transcriptional regulator 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CASP8AP2 caspase 8 associated protein 2
CCNF cyclin F
CD200 CD200 molecule
CDK12 cyclin-dependent kinase 12
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP170 centrosomal protein 170kDa
CEP192 centrosomal protein 192kDa
CEP55 centrosomal protein 55kDa
CHD9 chromodomain helicase DNA binding protein 9
CNOT4 CCR4-NOT transcription complex, subunit 4
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CX3CR1 chemokine (C-X3-C motif) receptor 1
DMBT1 deleted in malignant brain tumors 1
DUSP3 dual specificity phosphatase 3
E2F2 E2F transcription factor 2
EDRF1 erythroid differentiation regulatory factor 1
ELANE elastase, neutrophil expressed
FAM216A family with sequence similarity 216, member A
FKSG49 FKSG49
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
GABPB1 GA binding protein transcription factor, beta subunit 1
GLI2 GLI family zinc finger 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HOPX HOP homeobox
IFI44L interferon-induced protein 44-like
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LOC100272216 uncharacterized LOC100272216
LYST lysosomal trafficking regulator
LYZ lysozyme
MAP2K5 mitogen-activated protein kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MGA MGA, MAX dimerization protein
MGLL monoglyceride lipase
MPHOSPH9 M-phase phosphoprotein 9
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
N4BP2L2 NEDD4 binding protein 2-like 2
NFIB nuclear factor I/B
NFX1 nuclear transcription factor, X-box binding 1
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PDE10A phosphodiesterase 10A
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRKCA protein kinase C, alpha
RAD9A RAD9 homolog A (S. pombe)
RNF111 ring finger protein 111
RPL31 ribosomal protein L31
S100PBP S100P binding protein
SENP6 SUMO1/sentrin specific peptidase 6
SETX senataxin
SFTPB surfactant protein B
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLK STE20-like kinase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SYNRG synergin, gamma
TBC1D31 TBC1 domain family, member 31
TERF2 telomeric repeat binding factor 2
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THOC2 THO complex 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBGCP3 tubulin, gamma complex associated protein 3
UBE3C ubiquitin protein ligase E3C
ZC3H4 zinc finger CCCH-type containing 4
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF573 zinc finger protein 573
ZNF586 zinc finger protein 586