BRD-K53417444_OTSSP167_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K53417444_OTSSP167_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AHCY adenosylhomocysteinase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASRGL1 asparaginase like 1
BAG1 BCL2-associated athanogene
C2CD2L C2CD2-like
C6ORF48 chromosome 6 open reading frame 48
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCR2 chemokine (C-C motif) receptor 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CKB creatine kinase, brain
CPD carboxypeptidase D
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEFA4 defensin, alpha 4, corticostatin
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F2R coagulation factor II (thrombin) receptor
FAM171A1 family with sequence similarity 171, member A1
FAP fibroblast activation protein, alpha
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
G0S2 G0/G1 switch 2
GCLC glutamate-cysteine ligase, catalytic subunit
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HDAC9 histone deacetylase 9
HEG1 heart development protein with EGF-like domains 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP7 insulin-like growth factor binding protein 7
IGKV4-1 immunoglobulin kappa variable 4-1
IL6R interleukin 6 receptor
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0485 uncharacterized LOC57235
LAMP3 lysosomal-associated membrane protein 3
LDHB lactate dehydrogenase B
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MIR22HG MIR22 host gene
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSX1 msh homeobox 1
MT1E metallothionein 1E
NRGN neurogranin (protein kinase C substrate, RC3)
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
PCBP2 poly(rC) binding protein 2
PCDH7 protocadherin 7
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE8B phosphodiesterase 8B
PER2 period circadian clock 2
PLIN1 perilipin 1
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD9A RAD9 homolog A (S. pombe)
RHOBTB3 Rho-related BTB domain containing 3
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SHOX2 short stature homeobox 2
SIK1 salt-inducible kinase 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMNDC1 survival motor neuron domain containing 1
STC1 stanniocalcin 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
UBE2G2 ubiquitin-conjugating enzyme E2G 2
VLDLR very low density lipoprotein receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP5 WW domain binding protein 5
WSB1 WD repeat and SOCS box containing 1
XAF1 XIAP associated factor 1
XIST X inactive specific transcript (non-protein coding)
ZCCHC24 zinc finger, CCHC domain containing 24
ZMAT3 zinc finger, matrin-type 3
ZNF131 zinc finger protein 131
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADGRG2 adhesion G protein-coupled receptor G2
AIM1 absent in melanoma 1
AMDHD2 amidohydrolase domain containing 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BAMBI BMP and activin membrane-bound inhibitor
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CACYBP calcyclin binding protein
CALML3 calmodulin-like 3
CCNB2 cyclin B2
CCNC cyclin C
CD24 CD24 molecule
CD53 CD53 molecule
CD9 CD9 molecule
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CGRRF1 cell growth regulator with ring finger domain 1
DCK deoxycytidine kinase
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DSTN destrin (actin depolymerizing factor)
ECT2 epithelial cell transforming 2
EIF5 eukaryotic translation initiation factor 5
EPHA3 EPH receptor A3
FCGBP Fc fragment of IgG binding protein
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFV H2A histone family, member V
HK1 hexokinase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IVNS1ABP influenza virus NS1A binding protein
KRT19 keratin 19, type I
LBR lamin B receptor
LXN latexin
LYPLA1 lysophospholipase I
MAL mal, T-cell differentiation protein
MGP matrix Gla protein
MREG melanoregulin
MRPL18 mitochondrial ribosomal protein L18
NDC80 NDC80 kinetochore complex component
NRIP1 nuclear receptor interacting protein 1
NUP88 nucleoporin 88kDa
PAPOLA poly(A) polymerase alpha
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PEX3 peroxisomal biogenesis factor 3
PLN phospholamban
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51C RAD51 paralog C
SCRG1 stimulator of chondrogenesis 1
SMS spermine synthase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STAMBP STAM binding protein
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCP1 t-complex 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
UBE2C ubiquitin-conjugating enzyme E2C
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAM1 vascular cell adhesion molecule 1
VGLL4 vestigial-like family member 4
ZNF185 zinc finger protein 185 (LIM domain)