BRD-K53417444_OTSSP167_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-K53417444_OTSSP167_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
ANKRD10 ankyrin repeat domain 10
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASPN asporin
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
AZU1 azurocidin 1
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
CCNL1 cyclin L1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CUX1 cut-like homeobox 1
CXCL8 chemokine (C-X-C motif) ligand 8
DIO2 deiodinase, iodothyronine, type II
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EIF4A1 eukaryotic translation initiation factor 4A1
ELANE elastase, neutrophil expressed
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
GALC galactosylceramidase
GLA galactosidase, alpha
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
HEXIM1 hexamethylene bis-acetamide inducible 1
HHEX hematopoietically expressed homeobox
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IL6R interleukin 6 receptor
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ITGA7 integrin, alpha 7
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KLHL21 kelch-like family member 21
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LHX2 LIM homeobox 2
LINC00341 long intergenic non-protein coding RNA 341
LOX lysyl oxidase
LPPR4 lipid phosphate phosphatase-related protein type 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALT1 MALT1 paracaspase
MAPT microtubule-associated protein tau
MICB MHC class I polypeptide-related sequence B
MME membrane metallo-endopeptidase
MOAP1 modulator of apoptosis 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSX1 msh homeobox 1
MSX2 msh homeobox 2
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NOTCH2NL notch 2 N-terminal like
NPTX2 neuronal pentraxin II
NUPL1 nucleoporin like 1
OBSL1 obscurin-like 1
OLFML2A olfactomedin-like 2A
OMD osteomodulin
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHYH phytanoyl-CoA 2-hydroxylase
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RAB4A RAB4A, member RAS oncogene family
RGS16 regulator of G-protein signaling 16
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNMT RNA (guanine-7-) methyltransferase
RPS5 ribosomal protein S5
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMYD3 SET and MYND domain containing 3
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRED2 sprouty-related, EVH1 domain containing 2
SSPN sarcospan
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TCF4 transcription factor 4
TRIM2 tripartite motif containing 2
TRIP6 thyroid hormone receptor interactor 6
TSPAN7 tetraspanin 7
TWIST1 twist family bHLH transcription factor 1
UBE3B ubiquitin protein ligase E3B
WBP5 WW domain binding protein 5
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIDA axin interactor, dorsalization associated
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ANXA4 annexin A4
ANXA7 annexin A7
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
C7 complement component 7
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSF1R colony stimulating factor 1 receptor
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAPK1 death-associated protein kinase 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP1 fatty acid binding protein 1, liver
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FERMT1 fermitin family member 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FH fumarate hydratase
FLNA filamin A, alpha
FLNB filamin B, beta
FXYD3 FXYD domain containing ion transport regulator 3
GALE UDP-galactose-4-epimerase
GATA6 GATA binding protein 6
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KLF5 Kruppel-like factor 5 (intestinal)
KRT20 keratin 20, type I
LAMB1 laminin, beta 1
LBR lamin B receptor
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MBNL1 muscleblind-like splicing regulator 1
MECOM MDS1 and EVI1 complex locus
MGP matrix Gla protein
MUC4 mucin 4, cell surface associated
MYH11 myosin, heavy chain 11, smooth muscle
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NIT2 nitrilase family, member 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PODXL podocalyxin-like
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCARB2 scavenger receptor class B, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFTPC surfactant protein C
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOSTDC1 sclerostin domain containing 1
STAMBP STAM binding protein
TAGLN transgelin
TAGLN2 transgelin 2
TCTN1 tectonic family member 1
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VWF von Willebrand factor
WDR61 WD repeat domain 61
XK X-linked Kx blood group