BRD-K53417444_OTSSP167_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K53417444_OTSSP167_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADAM12 ADAM metallopeptidase domain 12
ADGRF5 adhesion G protein-coupled receptor F5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMPH amphiphysin
AQP1 aquaporin 1 (Colton blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASMTL acetylserotonin O-methyltransferase-like
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATXN1 ataxin 1
BRD2 bromodomain containing 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1R complement component 1, r subcomponent
C6ORF48 chromosome 6 open reading frame 48
C9ORF16 chromosome 9 open reading frame 16
CAPG capping protein (actin filament), gelsolin-like
CCL19 chemokine (C-C motif) ligand 19
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCR2 chemokine (C-C motif) receptor 2
CDC42 cell division cycle 42
CFI complement factor I
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLU clusterin
CPD carboxypeptidase D
CTSB cathepsin B
CTSD cathepsin D
CXCL9 chemokine (C-X-C motif) ligand 9
DIO1 deiodinase, iodothyronine, type I
DIO2 deiodinase, iodothyronine, type II
DMTF1 cyclin D binding myb-like transcription factor 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
EREG epiregulin
F12 coagulation factor XII (Hageman factor)
FGFR4 fibroblast growth factor receptor 4
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GATAD1 GATA zinc finger domain containing 1
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GOLGA8H golgin A8 family, member H
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HCP5 HLA complex P5 (non-protein coding)
HHEX hematopoietically expressed homeobox
HIPK2 homeodomain interacting protein kinase 2
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOMER1 homer scaffolding protein 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IL1RN interleukin 1 receptor antagonist
IL6R interleukin 6 receptor
IRF9 interferon regulatory factor 9
JMJD6 jumonji domain containing 6
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM5A lysine (K)-specific demethylase 5A
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LRRC41 leucine rich repeat containing 41
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPT microtubule-associated protein tau
MBP myelin basic protein
MEG3 maternally expressed 3 (non-protein coding)
METRN meteorin, glial cell differentiation regulator
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NACA nascent polypeptide-associated complex alpha subunit
NEU1 sialidase 1 (lysosomal sialidase)
PDE8B phosphodiesterase 8B
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRDX2 peroxiredoxin 2
RBM39 RNA binding motif protein 39
RHOBTB3 Rho-related BTB domain containing 3
RPL31 ribosomal protein L31
RTN1 reticulon 1
S100A1 S100 calcium binding protein A1
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SF1 splicing factor 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMNDC1 survival motor neuron domain containing 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SRRM2 serine/arginine repetitive matrix 2
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCF4 transcription factor 4
TM7SF2 transmembrane 7 superfamily member 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM47 transmembrane protein 47
TP73-AS1 TP73 antisense RNA 1
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZC3H15 zinc finger CCCH-type containing 15
ZMYM2 zinc finger, MYM-type 2
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BLVRA biliverdin reductase A
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CD24 CD24 molecule
CDC20 cell division cycle 20
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
DCK deoxycytidine kinase
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DUSP14 dual specificity phosphatase 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA3 EPH receptor A3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
HEATR1 HEAT repeat containing 1
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KLF4 Kruppel-like factor 4 (gut)
KRT81 keratin 81, type II
LBR lamin B receptor
LDLR low density lipoprotein receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LUM lumican
MAGEA3 melanoma antigen family A3
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2B methionine adenosyltransferase II, beta
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MRPL18 mitochondrial ribosomal protein L18
MTUS1 microtubule associated tumor suppressor 1
NMI N-myc (and STAT) interactor
NT5E 5'-nucleotidase, ecto (CD73)
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLS1 plastin 1
PON3 paraoxonase 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAD23B RAD23 homolog B (S. cerevisiae)
RCC1 regulator of chromosome condensation 1
RGS2 regulator of G-protein signaling 2
S100A7 S100 calcium binding protein A7
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRI sorcin
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TAGLN2 transgelin 2
TBC1D4 TBC1 domain family, member 4
TMEM100 transmembrane protein 100
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRAPPC3 trafficking protein particle complex 3
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VCAN versican