BRD-K53417444_OTSSP167_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

224 genes differentially expressed following the BRD-K53417444_OTSSP167_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANGPTL2 angiopoietin-like 2
ANOS1 anosmin 1
AOX1 aldehyde oxidase 1
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BAG2 BCL2-associated athanogene 2
BAG6 BCL2-associated athanogene 6
BGN biglycan
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
C9ORF16 chromosome 9 open reading frame 16
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CD99 CD99 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CFH complement factor H
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL21A1 collagen, type XXI, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CPNE3 copine III
CTGF connective tissue growth factor
CTSD cathepsin D
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ELN elastin
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVI2B ecotropic viral integration site 2B
EXPH5 exophilin 5
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPR183 G protein-coupled receptor 183
GPRASP1 G protein-coupled receptor associated sorting protein 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HMGN5 high mobility group nucleosome binding domain 5
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDO1 indoleamine 2,3-dioxygenase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITM2A integral membrane protein 2A
KRT19 keratin 19, type I
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LOC100272216 uncharacterized LOC100272216
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MFAP4 microfibrillar-associated protein 4
MSX1 msh homeobox 1
MXRA5 matrix-remodelling associated 5
NBPF10 neuroblastoma breakpoint family, member 10
NGRN neugrin, neurite outgrowth associated
NID2 nidogen 2 (osteonidogen)
NMRK1 nicotinamide riboside kinase 1
NOTCH1 notch 1
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLAGL1 pleiomorphic adenoma gene-like 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKCB protein kinase C, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRD protein tyrosine phosphatase, receptor type, D
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH2D1A SH2 domain containing 1A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORD sorbitol dehydrogenase
SPARCL1 SPARC-like 1 (hevin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF4 transcription factor 4
TMSB15A thymosin beta 15a
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VWF von Willebrand factor
WSB1 WD repeat and SOCS box containing 1
XYLT1 xylosyltransferase I
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP1 A kinase (PRKA) anchor protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLTC clathrin, heavy chain (Hc)
CORO1C coronin, actin binding protein, 1C
CSE1L CSE1 chromosome segregation 1-like (yeast)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DRAM1 DNA-damage regulated autophagy modulator 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
FOXJ3 forkhead box J3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
HOXB7 homeobox B7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ITGB1BP1 integrin beta 1 binding protein 1
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT81 keratin 81, type II
MELK maternal embryonic leucine zipper kinase
MIA melanoma inhibitory activity
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PRPF4 pre-mRNA processing factor 4
PRR15L proline rich 15-like
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RNPS1 RNA binding protein S1, serine-rich domain
SHB Src homology 2 domain containing adaptor protein B
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZMYM2 zinc finger, MYM-type 2