BRD-K53414658_tivozanib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K53414658_tivozanib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
CDC42 cell division cycle 42
CES1 carboxylesterase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
ITGAV integrin, alpha V
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP3 latent transforming growth factor beta binding protein 3
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
PHLDA1 pleckstrin homology-like domain, family A, member 1
S100A6 S100 calcium binding protein A6
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
STC2 stanniocalcin 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNS1 tensin 1
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
ZMYM2 zinc finger, MYM-type 2
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACKR3 atypical chemokine receptor 3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
AUTS2 autism susceptibility candidate 2
BEX4 brain expressed, X-linked 4
C6ORF62 chromosome 6 open reading frame 62
CD14 CD14 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC7A C-type lectin domain family 7, member A
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DLK1 delta-like 1 homolog (Drosophila)
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FTH1 ferritin, heavy polypeptide 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDO1 indoleamine 2,3-dioxygenase 1
MTSS1 metastasis suppressor 1
NLGN4X neuroligin 4, X-linked
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTK2 protein tyrosine kinase 2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRR1A small proline-rich protein 1A
SQLE squalene epoxidase
TIMP3 TIMP metallopeptidase inhibitor 3
TOX thymocyte selection-associated high mobility group box
TRIB2 tribbles pseudokinase 2
WBP5 WW domain binding protein 5