BRD-K53414658_-666_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K53414658_-666_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CFD complement factor D (adipsin)
CLIC4 chloride intracellular channel 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLD dihydrolipoamide dehydrogenase
ENO2 enolase 2 (gamma, neuronal)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
KRT19 keratin 19, type I
MTSS1 metastasis suppressor 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCP4 Purkinje cell protein 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PSAT1 phosphoserine aminotransferase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3YL1 SH3 and SYLF domain containing 1
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANPEP alanyl (membrane) aminopeptidase
CALML5 calmodulin-like 5
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42 cell division cycle 42
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
FZD10 frizzled class receptor 10
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IVL involucrin
JMJD6 jumonji domain containing 6
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
MTERF3 mitochondrial transcription termination factor 3
NEB nebulin
PALMD palmdelphin
PBX3 pre-B-cell leukemia homeobox 3
PI3 peptidase inhibitor 3, skin-derived
PTDSS1 phosphatidylserine synthase 1
RBP1 retinol binding protein 1, cellular
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SLPI secretory leukocyte peptidase inhibitor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TTN titin
TUBB4B tubulin, beta 4B class IVb