BRD-K53414658_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K53414658_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
BTG2 BTG family, member 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
NUPR1 nuclear protein, transcriptional regulator, 1
RAP1GAP RAP1 GTPase activating protein
SCPEP1 serine carboxypeptidase 1
SESN1 sestrin 1
SLC22A18 solute carrier family 22, member 18
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TGM2 transglutaminase 2
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ATAD2 ATPase family, AAA domain containing 2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CKS2 CDC28 protein kinase regulatory subunit 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HOXC6 homeobox C6
KIAA0101 KIAA0101
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
LYZ lysozyme
MCM6 minichromosome maintenance complex component 6
PBK PDZ binding kinase
PI3 peptidase inhibitor 3, skin-derived
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
TFRC transferrin receptor
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein