BRD-K53414658_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K53414658_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALOX15B arachidonate 15-lipoxygenase, type B
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD27 CD27 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC5 chloride intracellular channel 5
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FBXO11 F-box protein 11
FST follistatin
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GM2A GM2 ganglioside activator
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JCHAIN joining chain of multimeric IgA and IgM
KRT6B keratin 6B, type II
LAMP5 lysosomal-associated membrane protein family, member 5
NPIPB3 nuclear pore complex interacting protein family, member B3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RHOH ras homolog family member H
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STK10 serine/threonine kinase 10
SUCO SUN domain containing ossification factor
TOX thymocyte selection-associated high mobility group box
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
AK2 adenylate kinase 2
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ANXA4 annexin A4
AZU1 azurocidin 1
BRCA1 breast cancer 1, early onset
CAST calpastatin
CLEC11A C-type lectin domain family 11, member A
CPD carboxypeptidase D
CX3CR1 chemokine (C-X3-C motif) receptor 1
DPYD dihydropyrimidine dehydrogenase
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
F13A1 coagulation factor XIII, A1 polypeptide
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
HNMT histamine N-methyltransferase
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
KRT19 keratin 19, type I
KYNU kynureninase
LBP lipopolysaccharide binding protein
MYO5C myosin VC
MYOF myoferlin
NMT1 N-myristoyltransferase 1
NT5E 5'-nucleotidase, ecto (CD73)
PBX3 pre-B-cell leukemia homeobox 3
PLAC8 placenta-specific 8
PURA purine-rich element binding protein A
RHOB ras homolog family member B
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAMD4A sterile alpha motif domain containing 4A
SPRED2 sprouty-related, EVH1 domain containing 2
TMEM5 transmembrane protein 5
TPST2 tyrosylprotein sulfotransferase 2
UBE3C ubiquitin protein ligase E3C
VCAN versican