BRD-K53414658_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K53414658_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADGRG6 adhesion G protein-coupled receptor G6
AQP1 aquaporin 1 (Colton blood group)
ARHGAP5 Rho GTPase activating protein 5
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
COL3A1 collagen, type III, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
FAM13A family with sequence similarity 13, member A
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GNLY granulysin
GUSBP3 glucuronidase, beta pseudogene 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H1FX H1 histone family, member X
HIST1H2BG histone cluster 1, H2bg
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
LAMA4 laminin, alpha 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
MN1 meningioma (disrupted in balanced translocation) 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1D myosin ID
NARFL nuclear prelamin A recognition factor-like
NCOA2 nuclear receptor coactivator 2
NDRG1 N-myc downstream regulated 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTCH1 patched 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RTN1 reticulon 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TOX thymocyte selection-associated high mobility group box
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB1 defensin, beta 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EGR3 early growth response 3
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HOMER2 homer scaffolding protein 2
IER3 immediate early response 3
KLF6 Kruppel-like factor 6
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP16 NOP16 nucleolar protein
NUP98 nucleoporin 98kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI14 retinoic acid induced 14
RFTN1 raftlin, lipid raft linker 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase