BRD-K53414658_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K53414658_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
CCND2 cyclin D2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FGFR2 fibroblast growth factor receptor 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
MARS methionyl-tRNA synthetase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAT1 phosphoserine aminotransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SOX2 SRY (sex determining region Y)-box 2
TP53 tumor protein p53
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NPY neuropeptide Y
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
S100A2 S100 calcium binding protein A2
SOX9 SRY (sex determining region Y)-box 9
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2