BRD-K53308430_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K53308430_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
APOD apolipoprotein D
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CCL20 chemokine (C-C motif) ligand 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
COL14A1 collagen, type XIV, alpha 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD2 FXYD domain containing ion transport regulator 2
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
LYZ lysozyme
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
NEFL neurofilament, light polypeptide
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
PGK1 phosphoglycerate kinase 1
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PRAF2 PRA1 domain family, member 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROCR protein C receptor, endothelial
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RAB29 RAB29, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS4 regulator of G-protein signaling 4
S100P S100 calcium binding protein P
SCYL3 SCY1-like 3 (S. cerevisiae)
SELENBP1 selenium binding protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SRGN serglycin
STS steroid sulfatase (microsomal), isozyme S
SYT1 synaptotagmin I
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
WFDC2 WAP four-disulfide core domain 2
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
BLCAP bladder cancer associated protein
CDK6 cyclin-dependent kinase 6
CHD7 chromodomain helicase DNA binding protein 7
CLTB clathrin, light chain B
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMNA lamin A/C
PDGFA platelet-derived growth factor alpha polypeptide
PKP3 plakophilin 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SMAD1 SMAD family member 1
SOX11 SRY (sex determining region Y)-box 11
SPRR1B small proline-rich protein 1B
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91