BRD-K53281329_SYK-inhibitor_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K53281329_SYK-inhibitor_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ALB albumin
APOH apolipoprotein H (beta-2-glycoprotein I)
CAPN2 calpain 2, (m/II) large subunit
CD52 CD52 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ESR1 estrogen receptor 1
EXPH5 exophilin 5
FST follistatin
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
IER5 immediate early response 5
IL32 interleukin 32
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
MFAP5 microfibrillar associated protein 5
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
NPDC1 neural proliferation, differentiation and control, 1
NPR3 natriuretic peptide receptor 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PLSCR3 phospholipid scramblase 3
RGS10 regulator of G-protein signaling 10
S100A10 S100 calcium binding protein A10
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SFN stratifin
SH3YL1 SH3 and SYLF domain containing 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM4SF4 transmembrane 4 L six family member 4
TOB1 transducer of ERBB2, 1
VNN1 vanin 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
BMP7 bone morphogenetic protein 7
CRELD2 cysteine-rich with EGF-like domains 2
DLC1 DLC1 Rho GTPase activating protein
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
GEM GTP binding protein overexpressed in skeletal muscle
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPX3 glutathione peroxidase 3
HOXA5 homeobox A5
HP haptoglobin
JCHAIN joining chain of multimeric IgA and IgM
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NT5DC2 5'-nucleotidase domain containing 2
OLFM4 olfactomedin 4
PENK proenkephalin
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLK1 polo-like kinase 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
QKI QKI, KH domain containing, RNA binding
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLE4 transducin-like enhancer of split 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPYL5 TSPY-like 5