BRD-K52989797_Clomipramine hydrochloride_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K52989797_Clomipramine hydrochloride_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
APOD apolipoprotein D
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD36 CD36 molecule (thrombospondin receptor)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHN2 chimerin 2
COBL cordon-bleu WH2 repeat protein
CST3 cystatin C
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DMBT1 deleted in malignant brain tumors 1
EBP emopamil binding protein (sterol isomerase)
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUCA1 fucosidase, alpha-L- 1, tissue
GRAMD1B GRAM domain containing 1B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IL6 interleukin 6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LEPR leptin receptor
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NRN1 neuritin 1
PDE4DIP phosphodiesterase 4D interacting protein
PIP prolactin-induced protein
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZIC1 Zic family member 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ANXA10 annexin A10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AURKB aurora kinase B
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
EIF5A eukaryotic translation initiation factor 5A
FOLR1 folate receptor 1 (adult)
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
HIST1H1C histone cluster 1, H1c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
NDC80 NDC80 kinetochore complex component
NID1 nidogen 1
PBX3 pre-B-cell leukemia homeobox 3
RCAN2 regulator of calcineurin 2
RFTN1 raftlin, lipid raft linker 1
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SULF1 sulfatase 1
TOX thymocyte selection-associated high mobility group box
TSPAN12 tetraspanin 12
ZNF395 zinc finger protein 395