BRD-K52911425_GDC-0941_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K52911425_GDC-0941_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACACB acetyl-CoA carboxylase beta
AGR2 anterior gradient 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANGPT1 angiopoietin 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
CA1 carbonic anhydrase I
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CLU clusterin
COLEC12 collectin sub-family member 12
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CTSA cathepsin A
CXCL14 chemokine (C-X-C motif) ligand 14
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HIST1H2AC histone cluster 1, H2ac
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXB2 homeobox B2
HSPA2 heat shock 70kDa protein 2
ICA1 islet cell autoantigen 1, 69kDa
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LXN latexin
LY75 lymphocyte antigen 75
MAP7 microtubule-associated protein 7
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MLPH melanophilin
MSRA methionine sulfoxide reductase A
NET1 neuroepithelial cell transforming 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFD platelet derived growth factor D
PGAP3 post-GPI attachment to proteins 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
RFTN1 raftlin, lipid raft linker 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPAG16 sperm associated antigen 16
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SSBP2 single-stranded DNA binding protein 2
STAB1 stabilin 1
STON1 stonin 1
THBS1 thrombospondin 1
THBS3 thrombospondin 3
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPCN1 two pore segment channel 1
TRAPPC6A trafficking protein particle complex 6A
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VWF von Willebrand factor

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL4C ADP-ribosylation factor-like 4C
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CORO1C coronin, actin binding protein, 1C
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
EIF5A eukaryotic translation initiation factor 5A
GCLM glutamate-cysteine ligase, modifier subunit
GRB14 growth factor receptor-bound protein 14
IGFBP3 insulin-like growth factor binding protein 3
KRT14 keratin 14, type I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO1B myosin IB
NFIL3 nuclear factor, interleukin 3 regulated
NUSAP1 nucleolar and spindle associated protein 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRC1 protein regulator of cytokinesis 1
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPC25 SPC25, NDC80 kinetochore complex component
TGFBI transforming growth factor, beta-induced, 68kDa
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM45A transmembrane protein 45A
TOP1 topoisomerase (DNA) I
TYMS thymidylate synthetase