BRD-K52911425_GDC-0941_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K52911425_GDC-0941_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APLP2 amyloid beta (A4) precursor-like protein 2
ASS1 argininosuccinate synthase 1
AVPI1 arginine vasopressin-induced 1
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C5AR1 complement component 5a receptor 1
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CD14 CD14 molecule
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD9 CD9 molecule
CFD complement factor D (adipsin)
CHGB chromogranin B
CLU clusterin
COLEC12 collectin sub-family member 12
CREBL2 cAMP responsive element binding protein-like 2
CSTA cystatin A (stefin A)
CTSD cathepsin D
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DSP desmoplakin
EGFR epidermal growth factor receptor
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPX3 glutathione peroxidase 3
GRN granulin
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HLA-E major histocompatibility complex, class I, E
IFI27 interferon, alpha-inducible protein 27
ITGB4 integrin, beta 4
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOXL1 lysyl oxidase-like 1
LUM lumican
MFAP5 microfibrillar associated protein 5
MUC1 mucin 1, cell surface associated
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PINK1 PTEN induced putative kinase 1
PPL periplakin
PSAP prosaposin
RAB5B RAB5B, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
S100A14 S100 calcium binding protein A14
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SLC38A10 solute carrier family 38, member 10
SLC38A2 solute carrier family 38, member 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STEAP3 STEAP family member 3, metalloreductase
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEAL4 transcription elongation factor A (SII)-like 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM7SF2 transmembrane 7 superfamily member 2
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WISP2 WNT1 inducible signaling pathway protein 2
ZBTB16 zinc finger and BTB domain containing 16
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ARHGAP29 Rho GTPase activating protein 29
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLMH bleomycin hydrolase
CCND2 cyclin D2
CD200 CD200 molecule
CDC25A cell division cycle 25A
CENPN centromere protein N
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
ECI2 enoyl-CoA delta isomerase 2
EGR3 early growth response 3
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GLIPR1 GLI pathogenesis-related 1
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HOMER1 homer scaffolding protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
LEF1 lymphoid enhancer-binding factor 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEF2C myocyte enhancer factor 2C
MOCS2 molybdenum cofactor synthesis 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NRGN neurogranin (protein kinase C substrate, RC3)
PARP2 poly (ADP-ribose) polymerase 2
PLK1 polo-like kinase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHCBP1 SHC SH2-domain binding protein 1
SLIRP SRA stem-loop interacting RNA binding protein
SORD sorbitol dehydrogenase
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUB1 SUB1 homolog (S. cerevisiae)
TCP1 t-complex 1
TIPIN TIMELESS interacting protein
TMEM47 transmembrane protein 47
TPRKB TP53RK binding protein
YES1 YES proto-oncogene 1, Src family tyrosine kinase