BRD-K52911425_GDC-0941_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K52911425_GDC-0941_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
C1RL complement component 1, r subcomponent-like
CAMLG calcium modulating ligand
CD14 CD14 molecule
CD163 CD163 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHN2 chimerin 2
COCH cochlin
CST3 cystatin C
CTSK cathepsin K
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF4B eukaryotic translation initiation factor 4B
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXO4 forkhead box O4
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GRN granulin
GSE1 Gse1 coiled-coil protein
HIST1H2BD histone cluster 1, H2bd
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MTSS1 metastasis suppressor 1
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLD3 phospholipase D family, member 3
PRKCQ protein kinase C, theta
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP1 retinol binding protein 1, cellular
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
SYNGR3 synaptogyrin 3
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TRAPPC6A trafficking protein particle complex 6A
VCAN versican
VNN1 vanin 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AK4 adenylate kinase 4
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GOLM1 golgi membrane protein 1
GPI glucose-6-phosphate isomerase
HELLS helicase, lymphoid-specific
KIAA0101 KIAA0101
KIAA0355 KIAA0355
KRT7 keratin 7, type II
LIG1 ligase I, DNA, ATP-dependent
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL12 mitochondrial ribosomal protein L12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NEFH neurofilament, heavy polypeptide
NET1 neuroepithelial cell transforming 1
NRN1 neuritin 1
PBK PDZ binding kinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSMC3IP PSMC3 interacting protein
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPDL1 spindle apparatus coiled-coil protein 1
SPP1 secreted phosphoprotein 1
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMEM255A transmembrane protein 255A
TUBA4A tubulin, alpha 4a
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VEGFA vascular endothelial growth factor A
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein