BRD-K52911425_GDC-0941_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K52911425_GDC-0941_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
CREBL2 cAMP responsive element binding protein-like 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
ETV1 ets variant 1
EZR ezrin
FBXO11 F-box protein 11
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXG1 forkhead box G1
FXYD3 FXYD domain containing ion transport regulator 3
HMGB3 high mobility group box 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
LAMA3 laminin, alpha 3
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAOA monoamine oxidase A
MLPH melanophilin
MMP11 matrix metallopeptidase 11
MMP2 matrix metallopeptidase 2
MPDZ multiple PDZ domain protein
MUC4 mucin 4, cell surface associated
MYO5C myosin VC
N4BP2L1 NEDD4 binding protein 2-like 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSG1 neuron specific gene family member 1
NUP85 nucleoporin 85kDa
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
TCEA2 transcription elongation factor A (SII), 2
TMC5 transmembrane channel-like 5
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
AK4 adenylate kinase 4
APOA2 apolipoprotein A-II
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALU calumenin
CCL2 chemokine (C-C motif) ligand 2
CD36 CD36 molecule (thrombospondin receptor)
CKAP4 cytoskeleton-associated protein 4
CLIC3 chloride intracellular channel 3
COL9A3 collagen, type IX, alpha 3
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EGF epidermal growth factor
ELF5 E74-like factor 5 (ets domain transcription factor)
FAM162A family with sequence similarity 162, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF13 fibroblast growth factor 13
FKBP14 FK506 binding protein 14, 22 kDa
GGT1 gamma-glutamyltransferase 1
GLIPR1 GLI pathogenesis-related 1
GOLT1B golgi transport 1B
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
IRF4 interferon regulatory factor 4
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
MINA MYC induced nuclear antigen
NOTCH2 notch 2
NT5DC2 5'-nucleotidase domain containing 2
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PEX3 peroxisomal biogenesis factor 3
PGM1 phosphoglucomutase 1
PITX1 paired-like homeodomain 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SRPRB signal recognition particle receptor, B subunit
TFRC transferrin receptor
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TUBB2A tubulin, beta 2A class IIa
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)