BRD-K52911425_GDC-0941_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K52911425_GDC-0941_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
AHNAK2 AHNAK nucleoprotein 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATG14 autophagy related 14
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUH AU RNA binding protein/enoyl-CoA hydratase
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL6 B-cell CLL/lymphoma 6
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CA11 carbonic anhydrase XI
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CERK ceramide kinase
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CP ceruloplasmin (ferroxidase)
CPVL carboxypeptidase, vitellogenic-like
CREBL2 cAMP responsive element binding protein-like 2
CTSH cathepsin H
CTSV cathepsin V
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
ERBB3 erb-b2 receptor tyrosine kinase 3
ETHE1 ethylmalonic encephalopathy 1
F13A1 coagulation factor XIII, A1 polypeptide
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GRN granulin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
KDM3A lysine (K)-specific demethylase 3A
KIAA0430 KIAA0430
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMB2 laminin, beta 2 (laminin S)
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
MAN2B1 mannosidase, alpha, class 2B, member 1
MBTPS1 membrane-bound transcription factor peptidase, site 1
MET MET proto-oncogene, receptor tyrosine kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NBR1 neighbor of BRCA1 gene 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PYCARD PYD and CARD domain containing
RAB13 RAB13, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RALGDS ral guanine nucleotide dissociation stimulator
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1CC1 RB1-inducible coiled-coil 1
RBM47 RNA binding motif protein 47
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF103 ring finger protein 103
RNMT RNA (guanine-7-) methyltransferase
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SERINC3 serine incorporator 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNX1 sorting nexin 1
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
STAB1 stabilin 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM50A transmembrane protein 50A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ATF5 activating transcription factor 5
BOP1 block of proliferation 1
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPN centromere protein N
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL5A1 collagen, type V, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DHCR7 7-dehydrocholesterol reductase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
ELOVL1 ELOVL fatty acid elongase 1
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EXOSC2 exosome component 2
EXOSC8 exosome component 8
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IPO5 importin 5
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAK16 MAK16 homolog (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINA MYC induced nuclear antigen
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCH2 mitochondrial carrier 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRG1 neuregulin 1
NUP155 nucleoporin 155kDa
NUP88 nucleoporin 88kDa
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH9 protocadherin 9
PFKP phosphofructokinase, platelet
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RAD51 RAD51 recombinase
RALB v-ral simian leukemia viral oncogene homolog B
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SDF2L1 stromal cell-derived factor 2-like 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC43A3 solute carrier family 43, member 3
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
STIP1 stress-induced phosphoprotein 1
TCL1A T-cell leukemia/lymphoma 1A
TCP1 t-complex 1
TGFA transforming growth factor, alpha
TIPIN TIMELESS interacting protein
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VRK1 vaccinia related kinase 1
WDR43 WD repeat domain 43
WSB2 WD repeat and SOCS box containing 2