BRD-K52911425_GDC-0941_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K52911425_GDC-0941_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AMPD3 adenosine monophosphate deaminase 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
AOX1 aldehyde oxidase 1
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1RL complement component 1, r subcomponent-like
CD59 CD59 molecule, complement regulatory protein
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CLU clusterin
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FBN1 fibrillin 1
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
FSTL1 follistatin-like 1
GAA glucosidase, alpha; acid
GNB5 guanine nucleotide binding protein (G protein), beta 5
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MT2A metallothionein 2A
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NT5E 5'-nucleotidase, ecto (CD73)
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPAP2C phosphatidic acid phosphatase type 2C
PXDN peroxidasin
RABGAP1L RAB GTPase activating protein 1-like
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIN2 Ras and Rab interactor 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SGCE sarcoglycan, epsilon
SH3BGRL SH3 domain binding glutamate-rich protein like
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SSFA2 sperm specific antigen 2
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
USP6NL USP6 N-terminal like

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL6A1 collagen, type VI, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5 eukaryotic translation initiation factor 5
FABP7 fatty acid binding protein 7, brain
HIST1H2BG histone cluster 1, H2bg
HOXC10 homeobox C10
IARS isoleucyl-tRNA synthetase
INPP5F inositol polyphosphate-5-phosphatase F
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCAM1 neural cell adhesion molecule 1
ODC1 ornithine decarboxylase 1
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSAT1 phosphoserine aminotransferase 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SEPT11 septin 11
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
STC2 stanniocalcin 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN7 tetraspanin 7
TXNDC9 thioredoxin domain containing 9
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)