BRD-K52911425_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

40 genes differentially expressed following the BRD-K52911425_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ARMCX1 armadillo repeat containing, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLEC11A C-type lectin domain family 11, member A
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
ERBB3 erb-b2 receptor tyrosine kinase 3
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDPS farnesyl diphosphate synthase
FST follistatin
H1F0 H1 histone family, member 0
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
C8ORF4 chromosome 8 open reading frame 4
CDC25A cell division cycle 25A
DUSP2 dual specificity phosphatase 2
FOXF1 forkhead box F1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
LYPLA1 lysophospholipase I
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2