BRD-K52522949_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

269 genes differentially expressed following the BRD-K52522949_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ANOS1 anosmin 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCNG2 cyclin G2
CD22 CD22 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CETN2 centrin, EF-hand protein, 2
CHMP1B charged multivesicular body protein 1B
CLIC5 chloride intracellular channel 5
COG5 component of oligomeric golgi complex 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CP ceruloplasmin (ferroxidase)
CTSA cathepsin A
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETNPPL ethanolamine-phosphate phospho-lyase
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FOXO4 forkhead box O4
GABARAPL2 GABA(A) receptor-associated protein-like 2
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GRN granulin
GUK1 guanylate kinase 1
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HNMT histamine N-methyltransferase
HPCAL1 hippocalcin-like 1
HRSP12 heat-responsive protein 12
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KIAA1033 KIAA1033
LCK LCK proto-oncogene, Src family tyrosine kinase
LDHB lactate dehydrogenase B
LMO3 LIM domain only 3 (rhombotin-like 2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPIN1 lipin 1
LPIN2 lipin 2
LPXN leupaxin
LTA4H leukotriene A4 hydrolase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MGST3 microsomal glutathione S-transferase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
NCAM1 neural cell adhesion molecule 1
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NPTX2 neuronal pentraxin II
OPTN optineurin
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PHYH phytanoyl-CoA 2-hydroxylase
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNMA2 paraneoplastic Ma antigen 2
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB29 RAB29, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFTN1 raftlin, lipid raft linker 1
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
SC5D sterol-C5-desaturase
SCML1 sex comb on midleg-like 1 (Drosophila)
SCPEP1 serine carboxypeptidase 1
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17A serine/threonine kinase 17a
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNS1 tensin 1
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VIM vimentin
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AIM1 absent in melanoma 1
AKAP8 A kinase (PRKA) anchor protein 8
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
COL4A6 collagen, type IV, alpha 6
CRABP2 cellular retinoic acid binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTD dCMP deaminase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FHL2 four and a half LIM domains 2
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GPX2 glutathione peroxidase 2
GREB1 growth regulation by estrogen in breast cancer 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRWD1 glutamate-rich WD repeat containing 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IGFBP6 insulin-like growth factor binding protein 6
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LMNB1 lamin B1
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MICALL1 MICAL-like 1
MLPH melanophilin
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POSTN periostin, osteoblast specific factor
PRR7 proline rich 7 (synaptic)
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCUBE2 signal peptide, CUB domain, EGF-like 2
SENP6 SUMO1/sentrin specific peptidase 6
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFPQ splicing factor proline/glutamine-rich
SFRP1 secreted frizzled-related protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TNS3 tensin 3
TP63 tumor protein p63
TPBG trophoblast glycoprotein
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
TSKU tsukushi, small leucine rich proteoglycan
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAN versican
WDR43 WD repeat domain 43
WDR74 WD repeat domain 74
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2