BRD-K52522949_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K52522949_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ADCY9 adenylate cyclase 9
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AOX1 aldehyde oxidase 1
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ASS1 argininosuccinate synthase 1
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CORO1A coronin, actin binding protein, 1A
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DGKA diacylglycerol kinase, alpha 80kDa
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECHDC3 enoyl CoA hydratase domain containing 3
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
LGALS1 lectin, galactoside-binding, soluble, 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
METRN meteorin, glial cell differentiation regulator
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MSMO1 methylsterol monooxygenase 1
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEB nebulin
NOTCH1 notch 1
NQO2 NAD(P)H dehydrogenase, quinone 2
OPTN optineurin
OSTM1 osteopetrosis associated transmembrane protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNN stannin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SST somatostatin
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUFT1 tuftelin 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VWA5A von Willebrand factor A domain containing 5A
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CNPY3 canopy FGF signaling regulator 3
COMT catechol-O-methyltransferase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
FOXA2 forkhead box A2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEMIN4 gem (nuclear organelle) associated protein 4
GPX2 glutathione peroxidase 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MED1 mediator complex subunit 1
MGST2 microsomal glutathione S-transferase 2
MRPL23 mitochondrial ribosomal protein L23
MRPS30 mitochondrial ribosomal protein S30
MRPS35 mitochondrial ribosomal protein S35
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PRR7 proline rich 7 (synaptic)
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REPIN1 replication initiator 1
RPP38 ribonuclease P/MRP 38kDa subunit
S100A7 S100 calcium binding protein A7
SF3B3 splicing factor 3b, subunit 3, 130kDa
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLK1 tousled-like kinase 1
TMEM5 transmembrane protein 5
TMPO thymopoietin
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCK2 uridine-cytidine kinase 2
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
XPO7 exportin 7