BRD-K52522949_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K52522949_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C14ORF132 chromosome 14 open reading frame 132
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD14 CD14 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLU clusterin
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DSTN destrin (actin depolymerizing factor)
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FADS3 fatty acid desaturase 3
FAM107A family with sequence similarity 107, member A
FBP1 fructose-1,6-bisphosphatase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FOXF1 forkhead box F1
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
GUK1 guanylate kinase 1
HIST1H1C histone cluster 1, H1c
HN1 hematological and neurological expressed 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
KIF1A kinesin family member 1A
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LIPA lipase A, lysosomal acid, cholesterol esterase
LYZ lysozyme
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MGST3 microsomal glutathione S-transferase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MVP major vault protein
NAGK N-acetylglucosamine kinase
NCF2 neutrophil cytosolic factor 2
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
PLS1 plastin 1
POR P450 (cytochrome) oxidoreductase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRD protein tyrosine phosphatase, receptor type, D
RAD9A RAD9 homolog A (S. pombe)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC46A3 solute carrier family 46, member 3
SRGN serglycin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFRC transferrin receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
AKAP8 A kinase (PRKA) anchor protein 8
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATF1 activating transcription factor 1
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
DCTD dCMP deaminase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP4 dual specificity phosphatase 4
EMP3 epithelial membrane protein 3
EREG epiregulin
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GEMIN4 gem (nuclear organelle) associated protein 4
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB7 homeobox B7
IGFBP6 insulin-like growth factor binding protein 6
ILF3 interleukin enhancer binding factor 3, 90kDa
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PFAS phosphoribosylformylglycinamidine synthase
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB13 RAB13, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SFRP1 secreted frizzled-related protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TFB2M transcription factor B2, mitochondrial
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
WDR82 WD repeat domain 82