BRD-K52459643_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K52459643_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C1S complement component 1, s subcomponent
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CENPU centromere protein U
CES1 carboxylesterase 1
CFB complement factor B
CPM carboxypeptidase M
CRISP3 cysteine-rich secretory protein 3
CTSS cathepsin S
CXCL2 chemokine (C-X-C motif) ligand 2
DEFB1 defensin, beta 1
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
GALC galactosylceramidase
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HLA-DRA major histocompatibility complex, class II, DR alpha
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KYNU kynureninase
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
MXRA5 matrix-remodelling associated 5
OAT ornithine aminotransferase
PFN2 profilin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRC protein tyrosine phosphatase, receptor type, C
RGS1 regulator of G-protein signaling 1
SCGB1D2 secretoglobin, family 1D, member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX9 SRY (sex determining region Y)-box 9

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
APOE apolipoprotein E
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
BHLHE40 basic helix-loop-helix family, member e40
C6ORF62 chromosome 6 open reading frame 62
CANX calnexin
CD24 CD24 molecule
CHGB chromogranin B
CLIC4 chloride intracellular channel 4
COPA coatomer protein complex, subunit alpha
DBN1 drebrin 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FKBP5 FK506 binding protein 5
FKSG49 FKSG49
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GCH1 GTP cyclohydrolase 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
IFRD2 interferon-related developmental regulator 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGB4 integrin, beta 4
KCTD12 potassium channel tetramerization domain containing 12
LOX lysyl oxidase
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
NEBL nebulette
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
PAX5 paired box 5
PLEC plectin
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTBP1 polypyrimidine tract binding protein 1
PTPRO protein tyrosine phosphatase, receptor type, O
RPL36 ribosomal protein L36
SCARB2 scavenger receptor class B, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM259 transmembrane protein 259
TMPRSS2 transmembrane protease, serine 2
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2