BRD-K52321331_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

257 genes differentially expressed following the BRD-K52321331_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
ANKRD12 ankyrin repeat domain 12
ANXA1 annexin A1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CHMP1B charged multivesicular body protein 1B
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELL2 elongation factor, RNA polymerase II, 2
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERO1L ERO1-like (S. cerevisiae)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FEM1C fem-1 homolog c (C. elegans)
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXD1 forkhead box D1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LOXL2 lysyl oxidase-like 2
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAM maltase-glucoamylase
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MORC4 MORC family CW-type zinc finger 4
MT1F metallothionein 1F
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRN1 neuritin 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK6 proprotein convertase subtilisin/kexin type 6
PER1 period circadian clock 1
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTRF polymerase I and transcript release factor
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP4 SH3-domain binding protein 4
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SRGN serglycin
SSFA2 sperm specific antigen 2
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX3 syntaxin 3
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPM4 tropomyosin 4
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFC vascular endothelial growth factor C
VIM vimentin
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AIM1 absent in melanoma 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
C14ORF132 chromosome 14 open reading frame 132
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
EIF5B eukaryotic translation initiation factor 5B
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTF3A general transcription factor IIIA
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGN3 high mobility group nucleosomal binding domain 3
HOPX HOP homeobox
HOXC6 homeobox C6
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
ISOC1 isochorismatase domain containing 1
KIAA1033 KIAA1033
KRT15 keratin 15, type I
KRT7 keratin 7, type II
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MREG melanoregulin
MYH10 myosin, heavy chain 10, non-muscle
NFIB nuclear factor I/B
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
PHB prohibitin
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRR15L proline rich 15-like
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
THAP11 THAP domain containing 11
TNS3 tensin 3
TOR1A torsin family 1, member A (torsin A)
ZFP36L2 ZFP36 ring finger protein-like 2