BRD-K52321331_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K52321331_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACLY ATP citrate lyase
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNI cyclin I
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNPY3 canopy FGF signaling regulator 3
CST7 cystatin F (leukocystatin)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
EIF3L eukaryotic translation initiation factor 3, subunit L
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FBN2 fibrillin 2
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
KDM3A lysine (K)-specific demethylase 3A
LCN2 lipocalin 2
LYST lysosomal trafficking regulator
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL2 muscleblind-like splicing regulator 2
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MME membrane metallo-endopeptidase
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NAP1L1 nucleosome assembly protein 1-like 1
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOTCH1 notch 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSAT1 phosphoserine aminotransferase 1
QPRT quinolinate phosphoribosyltransferase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
SYT1 synaptotagmin I
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
C3 complement component 3
C7 complement component 7
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS2L1 growth arrest-specific 2 like 1
GGCX gamma-glutamyl carboxylase
GOLT1B golgi transport 1B
GRB14 growth factor receptor-bound protein 14
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGN3 high mobility group nucleosomal binding domain 3
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA14 heat shock 70kDa protein 14
KIF20A kinesin family member 20A
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT14 keratin 14, type I
LPL lipoprotein lipase
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCAM melanoma cell adhesion molecule
MECOM MDS1 and EVI1 complex locus
MRPS30 mitochondrial ribosomal protein S30
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PUF60 poly-U binding splicing factor 60KDa
SCAND1 SCAN domain containing 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SRSF6 serine/arginine-rich splicing factor 6
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNM synemin, intermediate filament protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPO thymopoietin
TOB1 transducer of ERBB2, 1
TXNL4A thioredoxin-like 4A
UBE2S ubiquitin-conjugating enzyme E2S
VTCN1 V-set domain containing T cell activation inhibitor 1
YME1L1 YME1-like 1 ATPase