BRD-K52321331_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K52321331_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADM adrenomedullin
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CALML3 calmodulin-like 3
CCL2 chemokine (C-C motif) ligand 2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEP57 centrosomal protein 57kDa
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CLDND1 claudin domain containing 1
COL6A1 collagen, type VI, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FMOD fibromodulin
FOSL1 FOS-like antigen 1
FRY furry homolog (Drosophila)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6 interleukin 6
IL7R interleukin 7 receptor
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPRK protein tyrosine phosphatase, receptor type, K
PTX3 pentraxin 3, long
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TP63 tumor protein p63
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
AHCY adenosylhomocysteinase
CCNF cyclin F
CDC20 cell division cycle 20
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPD carboxypeptidase D
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD2 interferon-related developmental regulator 2
IL17RB interleukin 17 receptor B
KIF20A kinesin family member 20A
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
QPRT quinolinate phosphoribosyltransferase