BRD-K52321331_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K52321331_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AK4 adenylate kinase 4
AUTS2 autism susceptibility candidate 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DEPTOR DEP domain containing MTOR-interacting protein
DST dystonin
FTH1 ferritin, heavy polypeptide 1
GLRX glutaredoxin (thioltransferase)
GPC4 glypican 4
GPR137B G protein-coupled receptor 137B
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MB myoglobin
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
OLFM4 olfactomedin 4
PDE4B phosphodiesterase 4B, cAMP-specific
PIGR polymeric immunoglobulin receptor
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTX3 pentraxin 3, long
RHOB ras homolog family member B
RIOK3 RIO kinase 3
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS2 sorbin and SH3 domain containing 2
SULF1 sulfatase 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOX3 TOX high mobility group box family member 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WDR7 WD repeat domain 7
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
B3GNT1
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CDKN3 cyclin-dependent kinase inhibitor 3
CHGB chromogranin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DPH2 DPH2 homolog (S. cerevisiae)
EBP emopamil binding protein (sterol isomerase)
EXOSC4 exosome component 4
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIF20A kinesin family member 20A
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
PNMA1 paraneoplastic Ma antigen 1
PODXL podocalyxin-like
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TP53BP2 tumor protein p53 binding protein 2
TRAPPC3 trafficking protein particle complex 3
UBE2S ubiquitin-conjugating enzyme E2S