BRD-K52163391_NCGC00165208-01_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K52163391_NCGC00165208-01_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
APOC3 apolipoprotein C-III
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIK BCL2-interacting killer (apoptosis-inducing)
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CD9 CD9 molecule
CDO1 cysteine dioxygenase type 1
CHD7 chromodomain helicase DNA binding protein 7
CLCA1 chloride channel accessory 1
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
COMP cartilage oligomeric matrix protein
CTH cystathionine gamma-lyase
DAAM1 dishevelled associated activator of morphogenesis 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFA6 defensin, alpha 6, Paneth cell-specific
DICER1 dicer 1, ribonuclease type III
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPEP1 dipeptidase 1 (renal)
ELMO1 engulfment and cell motility 1
EPHB2 EPH receptor B2
FABP1 fatty acid binding protein 1, liver
FAM117A family with sequence similarity 117, member A
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GCLC glutamate-cysteine ligase, catalytic subunit
GPX2 glutathione peroxidase 2
HBD hemoglobin, delta
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
JAG1 jagged 1
KLHL9 kelch-like family member 9
KRT20 keratin 20, type I
LEFTY1 left-right determination factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LRP4 low density lipoprotein receptor-related protein 4
LYPD1 LY6/PLAUR domain containing 1
MMD monocyte to macrophage differentiation-associated
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MTSS1 metastasis suppressor 1
NDRG1 N-myc downstream regulated 1
NOX1 NADPH oxidase 1
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAP2A RAP2A, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
RGS13 regulator of G-protein signaling 13
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SNAI2 snail family zinc finger 2
SRGN serglycin
SST somatostatin
SYT1 synaptotagmin I
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
TRAF5 TNF receptor-associated factor 5
TSKU tsukushi, small leucine rich proteoglycan
TSPAN12 tetraspanin 12
TXNRD1 thioredoxin reductase 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY1 adenylate cyclase 1 (brain)
AKAP7 A kinase (PRKA) anchor protein 7
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
APOD apolipoprotein D
ATAD2 ATPase family, AAA domain containing 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BHLHE41 basic helix-loop-helix family, member e41
CCL19 chemokine (C-C motif) ligand 19
CCL8 chemokine (C-C motif) ligand 8
CCNA2 cyclin A2
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CDC45 cell division cycle 45
CHPT1 choline phosphotransferase 1
COCH cochlin
CRYAB crystallin, alpha B
CTSD cathepsin D
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EGR1 early growth response 1
EGR3 early growth response 3
EIF4B eukaryotic translation initiation factor 4B
FGF13 fibroblast growth factor 13
FHL2 four and a half LIM domains 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HOXC6 homeobox C6
ICAM3 intercellular adhesion molecule 3
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LMNB1 lamin B1
LTF lactotransferrin
MCM5 minichromosome maintenance complex component 5
MLPH melanophilin
MUC1 mucin 1, cell surface associated
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOV nephroblastoma overexpressed
OSBPL1A oxysterol binding protein-like 1A
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PKP1 plakophilin 1
PLAC8 placenta-specific 8
PLIN1 perilipin 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PRSS23 protease, serine, 23
RCAN1 regulator of calcineurin 1
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A4RG SLC2A4 regulator
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORBS3 sorbin and SH3 domain containing 3
SPATS2L spermatogenesis associated, serine-rich 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR3 transforming growth factor, beta receptor III
TLK2 tousled-like kinase 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN4 tetraspanin 4
UBE2C ubiquitin-conjugating enzyme E2C
XBP1 X-box binding protein 1
ZNF512B zinc finger protein 512B