BRD-K52075715_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

158 genes differentially expressed following the BRD-K52075715_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CDA cytidine deaminase
CDC34 cell division cycle 34
COL18A1 collagen, type XVIII, alpha 1
COLEC12 collectin sub-family member 12
CST6 cystatin E/M
CST7 cystatin F (leukocystatin)
CUX2 cut-like homeobox 2
CXCL8 chemokine (C-X-C motif) ligand 8
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GPR161 G protein-coupled receptor 161
HACD1 3-hydroxyacyl-CoA dehydratase 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HOMER2 homer scaffolding protein 2
HOMER3 homer scaffolding protein 3
HPCAL1 hippocalcin-like 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
INHBB inhibin, beta B
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
LDLR low density lipoprotein receptor
LOC100286895 cell division cycle 27 homolog pseudogene
MEG3 maternally expressed 3 (non-protein coding)
MEX3D mex-3 RNA binding family member D
MPP1 membrane protein, palmitoylated 1, 55kDa
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NTS neurotensin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
S100A12 S100 calcium binding protein A12
SCD5 stearoyl-CoA desaturase 5
STX1A syntaxin 1A (brain)
TCL1A T-cell leukemia/lymphoma 1A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TPST2 tyrosylprotein sulfotransferase 2
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
ZYX zyxin

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ARMCX2 armadillo repeat containing, X-linked 2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BBX bobby sox homolog (Drosophila)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1S complement component 1, s subcomponent
C3 complement component 3
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CHEK2 checkpoint kinase 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPE carboxypeptidase E
CPNE3 copine III
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DICER1 dicer 1, ribonuclease type III
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
EDNRA endothelin receptor type A
EED embryonic ectoderm development
ESR1 estrogen receptor 1
FANCI Fanconi anemia, complementation group I
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNPDA1 glucosamine-6-phosphate deaminase 1
GSTM3 glutathione S-transferase mu 3 (brain)
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
KIAA0101 KIAA0101
KIF2C kinesin family member 2C
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBP myelin basic protein
MELK maternal embryonic leucine zipper kinase
MRPL49 mitochondrial ribosomal protein L49
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
NUSAP1 nucleolar and spindle associated protein 1
OGN osteoglycin
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PCYOX1 prenylcysteine oxidase 1
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SEH1L SEH1-like (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMC2 structural maintenance of chromosomes 2
SRSF11 serine/arginine-rich splicing factor 11
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TNS3 tensin 3
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1AIP1 torsin A interacting protein 1
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP1 ubiquitin specific peptidase 1
WWTR1 WW domain containing transcription regulator 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein