BRD-K52075040_-666_MCF7_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K52075040_-666_MCF7_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
C1S complement component 1, s subcomponent
CBR3 carbonyl reductase 3
CES1 carboxylesterase 1
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
LBH limb bud and heart development
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYC v-myc avian myelocytomatosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SORD sorbitol dehydrogenase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARMCX1 armadillo repeat containing, X-linked 1
B3GNT1
CD200 CD200 molecule
CD47 CD47 molecule
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
DEPTOR DEP domain containing MTOR-interacting protein
DPYD dihydropyrimidine dehydrogenase
EFNA1 ephrin-A1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KCTD12 potassium channel tetramerization domain containing 12
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR6 lysophosphatidic acid receptor 6
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PEG10 paternally expressed 10
PLAGL1 pleiomorphic adenoma gene-like 1
PON2 paraoxonase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RNF130 ring finger protein 130
SDC1 syndecan 1
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2