BRD-K52075040_-666_HEPG2_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K52075040_-666_HEPG2_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTC1 actin, alpha, cardiac muscle 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
CARS cysteinyl-tRNA synthetase
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CNOT4 CCR4-NOT transcription complex, subunit 4
COLEC12 collectin sub-family member 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSE dermatan sulfate epimerase
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
FLNC filamin C, gamma
GCLM glutamate-cysteine ligase, modifier subunit
GIMAP4 GTPase, IMAP family member 4
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
IFRD1 interferon-related developmental regulator 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC4 mucin 4, cell surface associated
NEB nebulin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCSK5 proprotein convertase subtilisin/kexin type 5
PLBD1 phospholipase B domain containing 1
PSAP prosaposin
PXDN peroxidasin
RIOK3 RIO kinase 3
S100A9 S100 calcium binding protein A9
SFRP4 secreted frizzled-related protein 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRGN serglycin
TALDO1 transaldolase 1
TBL1X transducin (beta)-like 1X-linked
TNPO1 transportin 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMD1 adenosylmethionine decarboxylase 1
AMDHD2 amidohydrolase domain containing 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOA2 apolipoprotein A-II
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CCNF cyclin F
CHI3L2 chitinase 3-like 2
CLDN3 claudin 3
CRIP1 cysteine-rich protein 1 (intestinal)
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPCAM epithelial cell adhesion molecule
FASN fatty acid synthase
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HES1 hes family bHLH transcription factor 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPPR4 lipid phosphate phosphatase-related protein type 4
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
NFIB nuclear factor I/B
NGRN neugrin, neurite outgrowth associated
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
RBP4 retinol binding protein 4, plasma
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SMYD2 SET and MYND domain containing 2
SOX9 SRY (sex determining region Y)-box 9
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAGLN2 transgelin 2
TFRC transferrin receptor
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYRP1 tyrosinase-related protein 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2